Skype is a portable application, which means it can be run from a USB flash drive, on any PC (even if Skype is not installed on the PC). This is useful when you are traveling and want to use Skype on a publicly available computer, for example, at a hotel, Internet cafe, library, etc.
How to set up Skype to run from a USB flash drive:
- Download Skype from http://skype.com and install it on your computer. (or, if you have already installed Skype on your computer, continue to step 2)
- Find the skype.exe file where it was installed. (Normally found at C:\Program Files\Skype\Phone\skype.exe)
- On your USB drive, create a folder and name it “Skype” and copy skype.exe into this folder
- Create another folder inside of the Skype folder on the USB drive and name it “Data”
- Create a new file in Notepad and name it “skype.bat” and add the following text: skype.exe /datapath:”Data” /removable
- Save the “skype.bat” file to the Data folder
That’s all! Now you are ready to run Skype from your USB drive. Just plug it into any PC and click on the skype.bat file. This will run Skype from your USB drive.
When you’re done, exit the Skype program, unplug the USB flash drive and go. Your call history, account settings and other personal Skype settings stay on your USB flash drive, not on the computer. This is a portable, “clean” and secure way to run Skype on any PC, without installing Skype.
Note: The first time you run Skype from your USB drive you may need to log into Skype with your SkypeID and password. On subsequent uses, you will be logged in automatically when you run “skype.bat.
Source: http://www.von-phone.com/portable-skype.php



